JYOTI JAGLAN*, ANDREW C. SINGER, PRAVEEN SHARMA AND SAVITA JAGLAN
Department of Environmental Science and Engineering, Guru Jambheshwar University of Science and Technology,
Hisar-125 001 (Haryana), India
*(e-mail : rs160481003@gjust.org; Mobile : 98127 22512)
(Received : April 29, 2022; Accepted : May 19, 2022)
ABSTRACT
The antimicrobial activity of Tinospora cordifolia aqueous extract was screened against gram-positive and
negative multiple drug-resistant (MDR) bacterial strains. Gram-positive included Bacillus cereus, Bacillus
paranthracis and gram-negative included Aeromonas hydrophila, Aeromonas caviae and Aeromonas dhakensis.
These strains were isolated from wastewater treatment plants having domestic and hospital discharge
and conferred resistance against most frequently used antibiotics. These multiple drug resistance
bacterial strains showed sensitivity towards aqueous extract of T. cordifolia. The present study concluded
that all selected bacterial strains showed a 17.9 mm lowest zone of inhibition and 33.9 mm highest in
the case of gram-positive bacteria. Similarly, in the case of gram-negative bacteria, the lowest of 19 mm
and the highest of 32.5 mm zone of inhibition.
Key words : Antimicrobial, multiple drug-resistant (MDR), aqueous extract, gram-positive, gram-negative