IRAQ HASAN IBRAHIM*, ASEEL NAJAH SABOUR AND FORAT ABD AL-HAMZAH HADI
Department of Biology, College of Education, University of Al-Qadisiyah, Iraq
*(e-mail: iraqmf79@gmail.com; Mobile: +964 78310 72028)
(Received: May 15, 2022; Accepted: July 18, 2022)
ABSTRACT
The current study was designed with the aim of determining some genetic effects and indicators on the
antioxidants caused by cisplatin, in addition to identifying the role played by the regular and nano-
extract of resveratrol in reducing the toxicity of the chemical drug caused by it. The 9-12 weeks male
rats were divided into six groups (ten animals per group). The results of the gene expression level of the drug group and the nano-extract showed a significant increase in the level of malodihydehyde (MDA)
and a decrease in the rest of the antigens (SOD, CAT, GSH) for the positive control group. Contrarily,
the results indicated a significant increase for the normal and nano-extract group when compared with
the positive control (G2) and other groups. Thus, the current study proved that giving the nano extract
showed a significant improvement compared to the normal extract, whether in the extract group alone
or simultaneously with the drug for its effective role in reducing the damage and toxic effects caused by
the drug.
Key words : Cisplatin, normal and nano-resveratrol extract, oxidative stress