MANDHEER KAUR*, SAHIL SHARMA, PREETI CHAUHAN, HARLEEN KHATRA, RENUKA SHARMA, ANKIT MAGOTRA, LOVE KUMAR, HARJODH SINGH AND CHAITANAYAJIT SINGH
Department of Biotechnology, Chandigarh Group of Colleges, Landran, Mohali-140 307 (Punjab), India
*(e-mail : mandheer.cct@cgc.edu.in; Mobile : 98885 68877)
(Received : December 20, 2021; Accepted : February 11, 2022)
ABSTRACT
Cardiovascular disease is very common worldwide. Low density lipoprotein (LDL) is one of the most
important factors which plays an important role in cardiovascular disease. The aim of this study was to
evaluate frequency distribution of LDL gene SNPs in CVD patients to find out any association with risk
of disease. The present study was carried out on blood samples collected from CVD suspected patients
to study risk of disease. The AA (wild type) and AB heterozygote genotype frequency were lower in
cardiovascular cases. In case of familial hypercholesterolemia (FH) percentage, frequency was higher in
heterozygous groups. Percentage frequency of wild type (AA) group was found lower. Allele frequency of
B allele was found more prevalent in patients affected with cardiovascular disease. Higher values of
total cholesterol, serum triglycerides, HDL, LDL and VLDL showed association with higher prevalence
of CVD risk factors. The present results suggested the difference of genotype distribution of LDL
polymorphism between cardiovascular patients; hence, established the association with risk of disease.
Further validation studies are required on additional LDL SNPs to study the CVD risk using larger
cohort.
Key words : : Cardiovascular disease, LDL, genotype, single nucleotide polymorphism (SNPs), lipid profile