TAREEK ABDULQADIR ABDAL* AND RAED SALIM AL-NAEMI
Department of Theriogenology, Physiology and Anatomy, College of Veterinary Medicine, University of Duhok,
Iraq
*(e-mail: tareek.abdal@uod.ac; Mobile : 075048 20824)
(Received: January 1, 2023; Accepted: February 1, 2023)
ABSTRACT
This study aimed at determining the influence of oxidative stress and lithogenic diet on rabbits’ gallstone
formation. Thirty-six healthy local mature rabbits of both genders were divided into six equal groups. 100% gallstones were formed in the GIII and 50% in the GIV. Serum levels of MDA, lipid profile, ALT, AST and ALP were significantly higher in GIII and GV when compared with the GI, while the serum levels of GR-activity and HDL-C were significantly lower in GIII and GV when compared with GI. It was concluded that rabbits exposed to imbalanced oxidative stress and fed a high-cholesterol diet could induce gallstone disease 100%.
Key words : Gallbladder stone, glutathione reductase, MDA, oxidative stress, lithogenic diet