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Phytochemical Analysis, Anti-oxidant Properties and PASS Assisted Prediction of Biological Activity of Sargassum wightti J. Agardh, Sargassum ilicifolium (Turner) C. Agardh and Sargassum lanceolatum J. Agardh

Mini Mol Jose and Jobi Xavier
Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru-560 029 (Karnatka), India
*(e-mail :; Mobile : 9916929979)
(Received : June 9, 2021; Accepted : August 12, 2021)


The present study was carried out to determine the phytoconstituents and anti-oxidant properties
present in the Sargassum wightti, Sargassum ilicifolium and Sargassum lanceolatum using GC-MS analysis
and predict the biological activity by PASS prediction. Gas chromatography/mass spectrometry (GC/MS)
analysis was performed on Shimadzu GC interfaced with mass spectrometry using SH-RxiTM-5Sil
(Shimadzu) column. The spectra of the phytoconstituents were obtained by the PASS version (http:// The prediction was based on an analysis of the structure-activity
relationships (SAR) in the training set containing information on the structure. GC-MS analysis revealed
39 compounds in S. wightti, 60 compounds in S. lanceolatum and 15 compounds in S. ilicifolium. Common
compounds found in these three Sargassum species were 1s,4R,7R,11R-1,3,4,7-Tetramethyltricyclo
[,11)] undec-2-en-8-one,2,4-Di-tert-butyl phenol, 1-Decanol, 2-hexyl, Hexatriacontyltrifluoroacetate, Nonyltetradecyl ether, Neophytadiene, Hexadecane. Sargassum species are rich in
anti-oxidant, anti-inflammatory, anti-bacterial and anti-viral properties. The present study proved the
presence of bioactive compounds and phytochemical compounds in three species of Sargassum available
in Indian coastal regions.
Key words : : Sargassum wightti, Sargassum ilicifolium, Sargassum lanceolatum, GC-MS, PASS prediction