AL-RUBAI, HAIDER K.*, M. L. RANIA, RANIA KAREEM HAMED, ASMAA A. JAWAD, ABBAS K. ABBAS, NADHUM HUSSEN SAFIR, SHAYMAA ALI ALKHAFAJI, DHUHA SALIM NAMAA, BAN AMEEN AND RANDA MOHAMMED
Department Molecular Genetics and DNA Fingerprinting, Forensic DNA Research and Training Center, Al-
Nahrain University, Jadriya, Baghdad, Iraq
*(e-mail: hayder khadum@yahoo.com; Mobile: 00960 79013 15232)
(Received: April 4, 2023; Accepted: May 9, 2023)
ABSTRACT
The present research work involved synthesizing derivatives of the chemical compound 1,3-oxazepine-
4,7-dione [F1-F2]. The synthesis was achieved using the [2-5] cycloaddition reaction of 1 mole maleic anhydride with azo-imine [D1-D2]. Additionally, the azo [C1-C2] was synthesized from p-hyroxyaniline by coupling diazonium salt with 4-alkoxy benzaldehyde. The structures of compounds F1 and F2 were characterized via spectroscopic technique. In this study this chemical compound was used against four different kinds of pathogenic bacteria, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. In addition to testing the growth inhibition of antibacterial antibiotics such as ampicillin and amoxicillin, the synthesized compounds F1 and F2 also showed positive results in terms of growth zone inhibition. In conclusion, a novel 1,3-oxazepine-4,7-dione derivative was created using Schiff’s base synthesis. Furthermore, the newly synthesized 1,3-oxazepine-4,7-dione compounds (F1, F2) were effective as antibacterial agent for S. aureus, B. subtilis, P. aerugiuosea and E. coli. Synthetic compounds showed similar biological activity to bacterial growth inhibitors, such as commonly used drugs like amoxicillin and penicillin, because the oxazepine-derived compounds contained many active groups that affect bacterial growth.
Key words : Antibiotics, 1,3-oxazepine, biological activity, bacteria