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The Comparative Effect of Copper Oxide Nanoparticles and Copper Sulfate on Reproductive Hormones and Sperm Parameters in Mature Male Albino Mice

Department of Biology, College of Education for Pure Science (Ibn-al-haitham), University of Baghdad, Iraq
*(e-mail :; Mobile : 00964 77223 10563)
(Received : April 4, 2022; Accepted : May 4, 2022)


Copper is one of the transitory elements that living beings require; any variations in the elements’
levels may have an impact on the reproductive system. The aim of this study was to compare how this
material influences the male reproductive organ by changing reproductive hormone levels and sperms
morphology in male albino mice after 14 days of oral gavages treatment of 25 and 35 mg/kg of CuO NPs
and CuSO4.5H2O. In comparison to the control (untreated mice), all of the animal treatments revealed a decrease in the sexual hormone levels and increased abnormality in sperm morphology and count. Both
in terms of concentrations, mice given copper sulfate had a greater effect on hormones and abnormality
than mice given copper oxide nanoparticles. The current study showed a comparison of CuONPs and CuSO4
.5H2O in terms of their capacity to cause acute systemic toxicity in response to oral insults.
Key words : Copper oxide nanoparticles, copper sulfate, male reproductive function, sperm morphology, fertilizes hormones