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Putative Role of yejF Salmonella typhi Gene in Human Macrophage Infection

Department of Chemistry & Biochemistry, CCS Haryana Agricultural University, Hisar-125 004 (Haryana), India
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(Received : November 5, 2017; Accepted : January 15, 2018)


Infections through the microbes are very common now-a-days due to change in lifestyle. Salmonella typhi is major agent that causes typhoid fever in humans which is growing very rapidly in developing countries. Approximately worldwide six lakhs annually deaths are reported due to S. typhi infection. Unhygienic conditions are the major issue for the development of typhoid fever in humans. S. typhi causes infection only in humans because of that knowledge about the pathogenicity is very less. Available antibiotics are not yet effective because S. typhi gets resistant to antibiotics effect by manipulating the involvement of genes in its infection. To design a new drug against the infection, firstly required the proper knowledge about the infection pathway, so that designed drug can interrupt the pathway of infection. The present study was conducted to assign the putative function to a yejF gene of S. typhi which is involved in causing the infection through the in silico study. This study found that yejF was a ABC transporter which transported the infectious material from bacteria to humans.

Key words : ABC transporter, infection, in silico, pathogenicity, Salmonella typhi, typhoid